San Francisco's iconic buildings have made it an ideal backdrop for many video games.
- Ace Combat: Joint Assault
- Alcatraz: Prison Escape
- Battletanx
- The Carmen Sandiego Series
- Destroy All Humans! 2
- Dirty Harry: The War Against Drugs
- Fallout 2
- Grand Theft Auto: San Andreas (as San Fierro)
- Indiana Jones and the Staff of Kings
- Manhunter 2: San Francisco
- Resistance 2
- Sonic Adventures 2
- The Tex Murphy Series
- Johnny Mosely: Mad Trix
San Francisco's twisting streets and dramatic hills have made it the setting of choice for many racing and driving video games.
- Blur
- Driver
- Driver: San Francisco
- Juiced 2: Hot Import Nights
- Need for Speed 2: The Run
- Rush 2: Extreme Racing USA
- San Francisco Rush
- San Francisco Rush 2049
- Top Gear Daredevil
In addition to its appearances within video games, San Francisco is a hotbed of creative activity when it comes to actually making them. Several video game publishers and developers call San Francisco home.